SPI1

Across TCGA pan-cancer cohorts, SPI1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPI1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SPI1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPI1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

GBM, PDAC, and UCEC are the cancer types where SPI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.345	0.671	.007	7	view →
PDAC	DFS	Median	III,IV	0.566	0.231	.021	4	view →
UCEC	OS	Tertile	All	1.000	0.845	.028	2	view →
LSCC	DFS	Tertile	II,III,IV	0.535	0.879	.033	2	view →
LUAD	OS	Quartile	III,IV	0.424	0.875	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPI1–GBM (OS)

Open the GBM breakdown →