SPI1

Across TCGA patient cohorts, SPI1 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPI1-associated genes across cancer lineages are Epithelial cells and Th2 cells. Each is linked with SPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPI1-to-partner and partner-to-SPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cells grouped by SPI1-low versus SPI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPI1→partner) and Y-score (partner→SPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Epithelial cells →	-0.085	-2.991	.030	.036	3	1
UCEC	Th2 cells →	+0.349	+3.169	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Epithelial cells by SPI1 expression — UCEC

Explore this box plot interactively →