SPI1

Across TCGA cell cohorts, SPI1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPI1-associated genes across cancer lineages are FCN2, CCDC42, and MBD3L2. Each is linked with SPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPI1-to-partner and partner-to-SPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by SPI1-low versus SPI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPI1→partner) and Y-score (partner→SPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCDC42 →	+0.033	+4.095	.008	.009	3	1
LARGE_INTESTINE	MBD3L2 →	+0.089	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GZMH →	+0.377	+3.886	<.001	.003	3	1
BLOOD_Leukemia	OPN4 →	+0.049	+4.121	<.001	<.001	3	1
BLOOD_Leukemia	PLA2G7 →	+0.459	+4.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FCN2 by SPI1 expression — LARGE_INTESTINE

Explore this box plot interactively →