SPHKAP

Across TCGA pan-cancer cohorts, SPHKAP Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated SPHKAP data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SPHKAP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPHKAP expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and KIRP are the cancer types where SPHKAP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.039	0.928	<.001	24	view →
UCEC	DFS	Median	All	0.921	0.611	.007	24	view →
KIRP	DFS	Median	II,III,IV	0.191	0.781	<.001	21	view →
LUAD	OS	Median	II,III,IV	0.053	0.751	<.001	18	view →
PAAD	DFS	Median	All	0.112	0.504	.025	6	view →
BRCA	OS	Median	All	0.451	0.581	.009	6	view →
PRAD	DFS	Median	All	0.572	0.889	<.001	6	view →
LUSC	DFS	Median	III,IV	0.245	0.540	.009	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LIHC	DFS	Median	II,III,IV	0.098	0.431	.007	6	view →
BLCA	OS	Median	II,III,IV	0.720	0.400	.040	4	view →
MESO	DFS	Median	All	1.000	0.179	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SPHKAP–THYM (OS)

Open the THYM breakdown →