SPHKAP

Across TCGA patient cohorts, SPHKAP mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPHKAP-associated genes across cancer lineages are GATA3, EGFR_pY1068, and p53. Each is linked with SPHKAP in more than 3 cancer types. Because this analysis shows association rather than direction, both SPHKAP-to-partner and partner-to-SPHKAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by SPHKAP-low versus SPHKAP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHKAP→partner) and Y-score (partner→SPHKAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GATA3 →	+0.133	+2.321	.005	.032	3	4
LUAD	EGFR_pY1068 →	-0.393	-3.000	.025	.034	3	3
LUAD	p53 →	+0.420	+3.169	<.001	.018	3	3
LUAD	PRDX1 →	+0.337	+2.601	<.001	.005	3	3
LUAD	ASNS →	+0.750	+3.459	<.001	.004	3	3
UCEC	Cyclin-B1 →	+0.621	+1.710	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

GATA3 by SPHKAP expression — LUAD

Explore this box plot interactively →