SPHKAP

Across TCGA cell cohorts, SPHKAP mutation is significantly associated with the RNA expression of many other genes, with 519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPHKAP-associated genes across cancer lineages are IFNA8, NOVA1, and FANCD2. Each is linked with SPHKAP in more than 2 cancer types. Because this analysis shows association rather than direction, both SPHKAP-to-partner and partner-to-SPHKAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by SPHKAP-low versus SPHKAP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHKAP→partner) and Y-score (partner→SPHKAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.052	+4.930	<.001	.008	3	3
BLOOD_Myeloma	NOVA1 →	+1.084	+3.044	<.001	.006	3	3
LARGE_INTESTINE	FANCD2 →	+0.552	+1.483	.001	.002	3	3
BLOOD_Myeloma	KLRC3 →	+0.028	+2.736	.001	.005	3	2
LUNG_SCLC	CUEDC2 →	-0.526	-3.169	.001	.003	3	2
LUNG_SCLC	SUFU →	-0.511	-2.210	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 519 associations by consensus.

IFNA8 by SPHKAP expression — SOFT_TISSUE

Explore this box plot interactively →