SPHK1

Across TCGA pan-cancer cohorts, SPHK1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPHK1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPHK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPHK1 expression acts as an unfavorable survival marker.

KIRP, SKCM, and ESCA are the cancer types where SPHK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.148	0.904	<.001	30	view →
SKCM	OS	Median	All	0.230	0.781	.004	24	view →
ESCA	DFS	Median	All	0.045	0.533	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPHK1–KIRP (OS)

Open the KIRP breakdown →