SPHK1

Across TCGA patient cohorts, SPHK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,450 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SPHK1-associated proteins across cancer lineages are FN1, RCN3, and BICD2. Each is linked with SPHK1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPHK1 versus FN1 in OV, with a Pearson correlation of 0.75.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+1.384	+1.350	<.001	<.001	3	9
OV	RCN3 →	+0.707	+1.243	<.001	<.001	3	9
LSCC	BICD2 →	+0.402	+0.750	<.001	<.001	3	8
GBM	C1R →	+0.647	+1.108	<.001	<.001	3	8
OV	C1S →	+0.629	+1.226	<.001	<.001	3	8
OV	CNN2 →	+0.892	+1.243	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,450 associations by consensus.

SPHK1 vs FN1 — OV

Explore this scatter interactively →