SPHK1

Across TCGA patient cohorts, SPHK1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPHK1-associated genes across cancer lineages are Cyclin-B1, ERK2, and FOXO3a_pS318_S321. Each is linked with SPHK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SPHK1-low versus SPHK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.764	+3.169	.004	.019	3	2
UCEC	ERK2 →	+0.226	+2.999	.015	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.162	-3.584	.007	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.274	-2.446	<.001	.020	3	1
UCEC	p62 Lck ligand →	+0.319	+2.459	.042	.020	3	1
UCEC	P-Cadherin →	-0.153	-2.999	.028	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Cyclin-B1 by SPHK1 expression — UCEC

Explore this box plot interactively →