SPHK1

Across TCGA cell cohorts, SPHK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,406 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPHK1-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Regulation of tumor necrosis factor-mediated signaling pathway, and Positive regulation of interleukin-17 production. Each is linked with SPHK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by SPHK1-low versus SPHK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of focal adhesion assembly →	+0.167	+1.982	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.096	+2.022	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of interleukin-17 production →	+0.141	+2.164	.004	.002	3	11
URINARY_TRACT	Response to oscillatory fluid shear stress →	+0.123	+1.875	<.001	.004	3	10
URINARY_TRACT	Cellular response to oscillatory fluid shear stress →	+0.123	+1.875	<.001	.004	3	10
URINARY_TRACT	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.123	+1.875	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,406 associations by consensus.

Positive regulation of focal adhesion assembly by SPHK1 expression — BONE

Explore this box plot interactively →