SPHK1

Across TCGA cell cohorts, SPHK1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPHK1-associated genes across cancer lineages are ETDC, WFDC12, and DEFB4A. Each is linked with SPHK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETDC grouped by SPHK1-low versus SPHK1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ETDC →	+0.483	+5.209	<.001	.005	3	1
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
LARGE_INTESTINE	GPR171 →	+0.021	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ETDC by SPHK1 expression — BLOOD_Lymphoma

Explore this box plot interactively →