SPHK1

Across TCGA cell cohorts, SPHK1 mutation is significantly associated with the mutation status of many other genes, with 3,092 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPHK1-associated genes across cancer lineages are PREP, FTMT, and ZNF708. Each is linked with SPHK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREP grouped by SPHK1-low versus SPHK1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PREP →	+5.014	+5.584	.003	.003	1	4
BLOOD_Leukemia	FTMT →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	ZNF708 →	+5.894	+5.321	.002	.002	1	3
BLOOD_Leukemia	EFCAB6 →	+3.479	+4.932	.002	.002	1	3
STOMACH	ZNF775 →	+4.807	+4.807	.008	.008	1	3
STOMACH	TSSK1B →	+4.807	+4.807	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,092 associations by consensus.

PREP by SPHK1 expression — BLOOD_Lymphoma

Explore this box plot interactively →