SPG21

Across TCGA pan-cancer cohorts, SPG21 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SPG21 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SPG21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPG21 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where SPG21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.806	1.000	.011	90	view →
LSCC	OS	Median	All	1.000	0.939	.013	9	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	8	view →
CCRCC	DFS	Tertile	III,IV	0.125	0.904	.024	8	view →
HNSC	OS	Median	III,IV	0.449	1.000	.023	6	view →
UCEC	DFS	Median	II,III,IV	0.550	0.865	.027	4	view →
GBM	DFS	Quartile	All	0.710	0.797	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SPG21–COAD (DFS)

Open the COAD breakdown →