SPG21

Across TCGA pan-cancer cohorts, SPG21 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPG21’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPG21 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SPG21 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where SPG21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPG21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.384	<.001	12	view →
HNSC	Male	All	+0.345	<.001	11	view →
LSCC	Male	II,III,IV	−0.280	<.001	8	view →
LUAD	Male	All	−0.212	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPG21–COAD

Open the COAD breakdown →