SPG21

Across TCGA patient cohorts, SPG21 mutation is significantly associated with the RNA expression of many other genes, with 561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPG21-associated genes across cancer lineages are RPL31P57, MIR6801, and TAAR5. Each is linked with SPG21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPG21-to-partner and partner-to-SPG21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL31P57 grouped by SPG21-low versus SPG21-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG21→partner) and Y-score (partner→SPG21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPL31P57 →	+0.183	+4.844	<.001	<.001	3	2
UCEC	MIR6801 →	+0.491	+2.443	.001	.002	3	2
SKCM	TAAR5 →	+0.079	+5.508	<.001	<.001	3	2
UCEC	RNU6-222P →	+0.581	+2.546	<.001	.004	3	2
UCEC	RNU6-558P →	+0.734	+2.186	<.001	.006	3	2
UCEC	RNU6-622P →	+0.222	+2.957	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 561 associations by consensus.

RPL31P57 by SPG21 expression — BLCA

Explore this box plot interactively →