SPG21

Across TCGA patient cohorts, SPG21 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPG21-associated genes across cancer lineages are PRAS40_pT246, Tuberin_pT1462, and Caspase-8. Each is linked with SPG21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPG21-to-partner and partner-to-SPG21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by SPG21-low versus SPG21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG21→partner) and Y-score (partner→SPG21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.188	+2.183	.036	.035	3	1
UCEC	Tuberin_pT1462 →	+0.328	+3.009	.006	.019	3	1
UCEC	Caspase-8 →	-0.261	-2.973	.047	.035	3	1
UCEC	14-3-3_beta →	-0.127	-2.979	.016	.036	2	1
UCEC	mTOR_pS2448 →	-0.235	-3.150	.002	.019	2	1
UCEC	BRD4 →	+0.408	+3.180	.003	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRAS40_pT246 by SPG21 expression — UCEC

Explore this box plot interactively →