SPG21

Across TCGA cell cohorts, SPG21 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,589 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPG21-associated GO terms across cancer lineages are RNA import into nucleus, Regulation of translation at postsynapse, modulating synaptic transmission, and Tricarboxylic acid cycle. Each is linked with SPG21 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPG21-to-partner and partner-to-SPG21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA import into nucleus grouped by SPG21-low versus SPG21-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG21→partner) and Y-score (partner→SPG21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNA import into nucleus →	+0.116	+0.666	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of translation at postsynapse, modulating synaptic transmission →	+0.107	+0.420	<.001	.005	3	7
LIVER	Tricarboxylic acid cycle →	+0.186	+0.865	<.001	.003	3	7
BLOOD_Lymphoma	Negative regulation of polyamine transmembrane transport →	+0.087	+0.685	.002	<.001	3	7
BLOOD_Lymphoma	Regulation of polyamine transmembrane transport →	+0.096	+0.539	<.001	.001	3	7
SOFT_TISSUE	Intracellular magnesium ion homeostasis →	+0.107	+0.637	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,589 associations by consensus.

RNA import into nucleus by SPG21 expression — PANCREAS

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