SPEM3

Across TCGA patient cohorts, SPEM3 RNA expression is significantly associated with the protein abundance of many other proteins, with 3,979 significant associations in total. OV shows the largest number of these associations.

The most reproducible SPEM3-associated proteins across cancer lineages are ARHGEF12_S1389, PALM3_S303, and PBDC1_S197. Each is linked with SPEM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPEM3-to-partner and partner-to-SPEM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPEM3 versus ARHGEF12_S1389 in OV, with a Pearson correlation of -0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM3→partner) and Y-score (partner→SPEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGEF12_S1389 →	-1.044	-0.095	.001	.001	3	3
LUAD	PALM3_S303 →	+1.339	+0.046	.001	.006	3	2
OV	PBDC1_S197 →	-0.654	-0.080	.001	.002	3	2
BRCA	SRRM2_S449 →	-0.797	-0.137	.009	.001	3	2
OV	SVIL_S914 →	+0.827	+0.105	.004	.002	3	2
OV	SYNPO_T783 →	-0.972	-0.073	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,979 associations by consensus.

SPEM3 vs ARHGEF12_S1389 — OV

Explore this scatter interactively →