SPEM3

Across TCGA cell cohorts, SPEM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 986 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPEM3-associated GO terms across cancer lineages are Base-excision repair, Positive regulation of transmembrane transport, and RNA splicing, via transesterification reactions. Each is linked with SPEM3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPEM3-to-partner and partner-to-SPEM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Base-excision repair grouped by SPEM3-low versus SPEM3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM3→partner) and Y-score (partner→SPEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Base-excision repair →	+0.075	+0.020	<.001	.004	3	6
LUNG_SCLC	Positive regulation of transmembrane transport →	-0.049	-0.018	.007	.009	3	6
OVARY	RNA splicing, via transesterification reactions →	+0.052	+0.021	.001	.004	3	6
BLOOD_Lymphoma	Regulation of respiratory gaseous exchange by nervous system process →	+1.078	+0.007	<.001	<.001	3	5
SOFT_TISSUE	DNA topological change →	+0.087	+0.017	<.001	.005	3	5
LUNG_NSCLC_LUAD	Establishment of mitotic spindle localization →	+0.071	+0.012	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 986 associations by consensus.

Base-excision repair by SPEM3 expression — LUNG_SCLC

Explore this box plot interactively →