Across TCGA patient cohorts, SPEM2 mutation is significantly associated with the RNA expression of many other genes, with 1,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEM2-associated genes across cancer lineages are KCNIP2-AS1, CRK, and HASPIN. Each is linked with SPEM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPEM2-to-partner and partner-to-SPEM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM2→partner) and Y-score (partner→SPEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNIP2-AS1 →	+0.250	+2.914	.005	.001	3	4
UCEC	CRK →	+0.387	+3.491	.002	.002	3	3
UCEC	HASPIN →	+0.755	+2.828	<.001	.001	3	3
UCEC	MAPK9 →	+0.361	+1.858	.003	.005	3	3
UCEC	IFRD1 →	+0.443	+2.337	.007	.003	3	3
UCEC	TIPIN →	+0.415	+2.269	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,393 associations by consensus.

Exploration

SPEM2 survival (RNA) · tumor vs normal (RNA) · all SPEM2 data types