Across TCGA patient cohorts, SPEM2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEM2-associated genes across cancer lineages are eIF4E, TIGAR, and mTOR_pS2448. Each is linked with SPEM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPEM2-to-partner and partner-to-SPEM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM2→partner) and Y-score (partner→SPEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+2.321	.049	.034	3	3
UCEC	TIGAR →	+0.148	+3.114	.015	<.001	3	3
COAD	mTOR_pS2448 →	-0.209	-2.313	.009	.035	3	2
COAD	RAD51 →	+0.270	+3.467	<.001	.002	3	2
COAD	STAT5a →	-0.749	-2.987	.002	.035	3	2
COAD	TSC1 →	-0.410	-2.313	<.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

SPEM2 survival (RNA) · tumor vs normal (RNA) · all SPEM2 data types