Across TCGA cell cohorts, SPEM2 mutation is significantly associated with the RNA expression of many other genes, with 547 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPEM2-associated genes across cancer lineages are KLHL40, C1QTNF7, and IL4. Each is linked with SPEM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPEM2-to-partner and partner-to-SPEM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM2→partner) and Y-score (partner→SPEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KLHL40 →	+0.007	+4.865	.001	<.001	3	2
LARGE_INTESTINE	C1QTNF7 →	+0.069	+2.523	<.001	.003	3	2
SKIN	IL4 →	+0.105	+4.047	<.001	<.001	3	1
SKIN	LAIR2 →	+0.090	+2.925	.001	.007	3	1
SKIN	KRTAP13-4 →	+0.017	+3.700	<.001	.009	3	1
SKIN	KRTAP1-3 →	+0.014	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 547 associations by consensus.

Exploration

SPEM2 survival (RNA) · tumor vs normal (RNA) · all SPEM2 data types