SPEF2

Across TCGA pan-cancer cohorts, SPEF2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPEF2 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPEF2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SPEF2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD and LSCC are the cancer types where SPEF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	1.000	0.535	.013	11	view →
LSCC	OS	Quartile	II,III,IV	0.346	0.854	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPEF2–LUAD (OS)

Open the LUAD breakdown →