SPEF2

Across TCGA patient cohorts, SPEF2 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEF2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and ASNS. Each is linked with SPEF2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPEF2-to-partner and partner-to-SPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SPEF2-low versus SPEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF2→partner) and Y-score (partner→SPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.264	+2.029	<.001	.001	3	5
STAD	Cyclin-B1 →	+0.595	+3.584	.003	.002	1	6
COAD	ASNS →	+0.459	+2.321	.001	.033	3	4
UCEC	PDCD4 →	-0.321	-1.152	.009	.044	3	4
SKCM	c-Kit →	-0.373	-1.041	.025	.009	3	3
COAD	FASN →	+0.410	+2.000	.003	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

4E-BP1 by SPEF2 expression — UCEC

Explore this box plot interactively →