SPEF2

Across TCGA cell cohorts, SPEF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,146 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPEF2-associated GO terms across cancer lineages are Golgi to plasma membrane protein transport, Regulation of myoblast fusion, and Cilium movement involved in cell motility. Each is linked with SPEF2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SPEF2-to-partner and partner-to-SPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi to plasma membrane protein transport grouped by SPEF2-low versus SPEF2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF2→partner) and Y-score (partner→SPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Golgi to plasma membrane protein transport →	+0.117	+1.292	.006	.001	2	13
STOMACH	Regulation of myoblast fusion →	+0.127	+1.572	.001	.001	2	13
KIDNEY	Cilium movement involved in cell motility →	-0.096	-1.303	<.001	<.001	3	11
KIDNEY	Cilium or flagellum-dependent cell motility →	-0.089	-1.210	<.001	<.001	3	10
KIDNEY	Cilium-dependent cell motility →	-0.089	-1.210	<.001	<.001	3	10
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.128	+1.589	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,146 associations by consensus.

Golgi to plasma membrane protein transport by SPEF2 expression — STOMACH

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