SPEF2

Across TCGA cell cohorts, SPEF2 mutation is significantly associated with the RNA expression of many other genes, with 1,207 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPEF2-associated genes across cancer lineages are FPGT, USP45, and BEND2. Each is linked with SPEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPEF2-to-partner and partner-to-SPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FPGT grouped by SPEF2-low versus SPEF2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF2→partner) and Y-score (partner→SPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FPGT →	+0.458	+3.212	.008	.006	2	4
LARGE_INTESTINE	USP45 →	+0.705	+2.265	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	BEND2 →	+0.022	+4.357	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	OR10R2 →	+0.112	+4.357	<.001	.006	3	3
SOFT_TISSUE	CPLX4 →	+0.030	+3.113	.002	.004	3	2
URINARY_TRACT	FUT5 →	+0.112	+4.372	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,207 associations by consensus.

FPGT by SPEF2 expression — SKIN

Explore this box plot interactively →