SPEF1

Across TCGA pan-cancer cohorts, SPEF1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPEF1 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPEF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPEF1 expression acts as an unfavorable survival marker.

HNSC and MESO are the cancer types where SPEF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.021	0.751	<.001	48	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPEF1–HNSC (OS)

Open the HNSC breakdown →