SPEF1

Across TCGA pan-cancer cohorts, SPEF1 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPEF1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPEF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPEF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC are the cancer types where SPEF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.649	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SPEF1–UCEC (DFS)

Open the UCEC breakdown →