SPEF1

Across TCGA patient cohorts, SPEF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,480 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPEF1-associated proteins across cancer lineages are OSCP1, WDR35, and LZTFL1. Each is linked with SPEF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPEF1-to-partner and partner-to-SPEF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPEF1 versus OSCP1 in BRCA, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF1→partner) and Y-score (partner→SPEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OSCP1 →	+0.651	+1.342	<.001	<.001	3	7
BRCA	WDR35 →	+0.378	+1.099	<.001	<.001	3	7
BRCA	LZTFL1 →	+0.596	+1.157	<.001	<.001	3	7
BRCA	IFT122 →	+0.420	+1.462	<.001	<.001	3	7
BRCA	IFT140 →	+0.609	+1.400	<.001	<.001	3	7
OV	IFT46 →	+0.485	+1.126	.009	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,480 associations by consensus.

SPEF1 vs OSCP1 — BRCA

Explore this scatter interactively →