SPEF1

Across TCGA patient cohorts, SPEF1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEF1-associated genes across cancer lineages are RN7SL510P, MIR340, and RNU6-83P. Each is linked with SPEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPEF1-to-partner and partner-to-SPEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL510P grouped by SPEF1-low versus SPEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF1→partner) and Y-score (partner→SPEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL510P →	+0.466	+3.220	<.001	.003	3	1
BLCA	MIR340 →	+0.402	+5.497	<.001	.004	3	1
BLCA	RNU6-83P →	+0.405	+5.177	<.001	.007	3	1
BLCA	MIR549A →	+0.461	+6.147	<.001	.002	3	1
BLCA	MIR6842 →	+0.600	+5.177	<.001	.007	3	1
COAD	RNU6-633P →	+1.118	+4.374	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

RN7SL510P by SPEF1 expression — UCEC

Explore this box plot interactively →