SPEF1

Across TCGA cell cohorts, SPEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,922 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPEF1-associated GO terms across cancer lineages are Transport along microtubule, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with SPEF1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPEF1-to-partner and partner-to-SPEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transport along microtubule grouped by SPEF1-low versus SPEF1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEF1→partner) and Y-score (partner→SPEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Transport along microtubule →	+0.051	+0.581	<.001	<.001	3	14
KIDNEY	Cilium or flagellum-dependent cell motility →	-0.080	-0.568	.002	.006	3	12
KIDNEY	Cilium-dependent cell motility →	-0.080	-0.568	.002	.006	3	12
KIDNEY	Cilium movement involved in cell motility →	-0.088	-0.621	.001	.003	3	12
LIVER	Protein localization to cilium →	+0.081	+0.881	.001	.007	3	12
CNS	Regulation of protein localization to endoplasmic reticulum →	+0.118	+0.267	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,922 associations by consensus.

Transport along microtubule by SPEF1 expression — BREAST

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