SPECC1

Across TCGA pan-cancer cohorts, SPECC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPECC1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPECC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPECC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where SPECC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.698	1.000	.020	26	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	21	view →
UCEC	DFS	Median	All	0.964	0.844	.004	14	view →
LSCC	DFS	Tertile	II,III,IV	0.569	0.906	.017	7	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPECC1–HNSC (DFS)

Open the HNSC breakdown →