SPECC1

Across TCGA patient cohorts, SPECC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,303 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPECC1-associated proteins across cancer lineages are SPECC1_S241, SPECC1_S361, and SPECC1_S914. Each is linked with SPECC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPECC1-to-partner and partner-to-SPECC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPECC1 versus SPECC1_S241 in LSCC, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1→partner) and Y-score (partner→SPECC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPECC1_S241 →	+1.038	+1.146	<.001	<.001	3	6
LSCC	SPECC1_S361 →	+0.560	+0.679	<.001	<.001	3	6
PDAC	SPECC1_S914 →	+0.704	+0.477	<.001	<.001	3	6
LSCC	P3H1 →	+0.448	+0.711	<.001	<.001	3	6
BRCA	COL5A1 →	+0.934	+0.600	<.001	.001	3	6
LSCC	SPECC1_S810 →	+0.863	+1.151	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,303 associations by consensus.

SPECC1 vs SPECC1_S241 — LSCC

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