SPECC1

Across TCGA patient cohorts, SPECC1 mutation is significantly associated with the RNA expression of many other genes, with 2,521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPECC1-associated genes across cancer lineages are LINC01784, RN7SKP2, and RPL17P45. Each is linked with SPECC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPECC1-to-partner and partner-to-SPECC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01784 grouped by SPECC1-low versus SPECC1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1→partner) and Y-score (partner→SPECC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	LINC01784 →	+0.104	+7.939	<.001	.008	3	3
LIHC	RN7SKP2 →	+0.089	+4.580	<.001	.004	3	2
LUSC	RPL17P45 →	+0.157	+4.984	<.001	.009	3	2
BLCA	OR2AH1P →	+0.067	+4.455	<.001	.005	3	2
LIHC	RNU6-13P →	+0.246	+3.479	<.001	.006	3	2
LIHC	DEFB116 →	+0.098	+5.592	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,521 associations by consensus.

LINC01784 by SPECC1 expression — PRAD

Explore this box plot interactively →