SPECC1

Across TCGA patient cohorts, SPECC1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPECC1-associated genes across cancer lineages are JNK2, Chk2_pT68, and ERK2. Each is linked with SPECC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPECC1-to-partner and partner-to-SPECC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SPECC1-low versus SPECC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1→partner) and Y-score (partner→SPECC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.146	+1.295	.011	.010	3	3
UCEC	Chk2_pT68 →	-0.138	-3.558	.011	.002	3	3
UCEC	ERK2 →	+0.156	+1.807	.005	.003	3	2
UCEC	INPP4B →	-0.212	-1.765	.024	.011	3	2
UCEC	Akt_pS473 →	+0.447	+1.584	.031	.032	3	2
COAD	p62 Lck ligand →	+0.423	+3.008	.035	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK2 by SPECC1 expression — UCEC

Explore this box plot interactively →