SPECC1

Across TCGA cell cohorts, SPECC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,649 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPECC1-associated GO terms across cancer lineages are Protein localization to vacuole, Golgi vesicle transport, and Endosomal transport. Each is linked with SPECC1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SPECC1-to-partner and partner-to-SPECC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to vacuole grouped by SPECC1-low versus SPECC1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1→partner) and Y-score (partner→SPECC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein localization to vacuole →	+0.069	+1.626	<.001	.003	3	11
BLOOD_Lymphoma	Golgi vesicle transport →	+0.048	+2.533	<.001	<.001	3	10
SKIN	Endosomal transport →	+0.047	+1.255	.001	.001	2	11
BONE	Establishment of protein localization to membrane →	+0.048	+1.576	.003	.001	3	9
BONE	Chaperone-mediated autophagy →	+0.146	+2.086	.004	<.001	3	9
CNS	Positive regulation of purine nucleotide biosynthetic process →	+0.146	+2.070	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,649 associations by consensus.

Protein localization to vacuole by SPECC1 expression — LUNG_NSCLC_LUSC

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