SPDYE6

Across TCGA pan-cancer cohorts, SPDYE6 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPDYE6 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SPDYE6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPDYE6 expression acts as an unfavorable survival marker.

SKCM are the cancer types where SPDYE6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.087	0.757	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SPDYE6–SKCM (DFS)

Open the SKCM breakdown →