SPDYE6

Across TCGA patient cohorts, SPDYE6 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SPDYE6-associated genes across cancer lineages are RNU6-461P, RAC1P6, and RNU6-929P. Each is linked with SPDYE6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE6-to-partner and partner-to-SPDYE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-461P grouped by SPDYE6-low versus SPDYE6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE6→partner) and Y-score (partner→SPDYE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-461P →	+0.773	+7.816	<.001	.008	3	1
SKCM	RAC1P6 →	+0.079	+7.816	<.001	.008	3	1
COAD	RNU6-929P →	+0.323	+7.741	<.001	.009	3	1
COAD	RBMY2GP →	+0.039	+7.741	<.001	.009	3	1
COAD	TRAPPC2P8 →	+0.164	+7.741	<.001	.009	3	1
COAD	MTCO3P30 →	+0.099	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RNU6-461P by SPDYE6 expression — SKCM

Explore this box plot interactively →