SPDYE6

Across TCGA cell cohorts, SPDYE6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,442 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPDYE6-associated GO terms across cancer lineages are Nuclear export, Pre-mRNA catabolic process, and Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with SPDYE6 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPDYE6-to-partner and partner-to-SPDYE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by SPDYE6-low versus SPDYE6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE6→partner) and Y-score (partner→SPDYE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.119	+1.098	<.001	<.001	3	16
BONE	Pre-mRNA catabolic process →	+0.215	+0.995	<.001	<.001	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.173	+0.852	<.001	<.001	3	16
BONE	Post-transcriptional gene silencing →	+0.086	+0.824	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of translational initiation →	+0.113	+1.097	<.001	.001	3	15
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.081	+0.804	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

Nuclear export by SPDYE6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →