SPDYE5

Across TCGA patient cohorts, SPDYE5 mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE5-associated genes across cancer lineages are CRYGA, MTATP6P21, and RNA5SP367. Each is linked with SPDYE5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE5-to-partner and partner-to-SPDYE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGA grouped by SPDYE5-low versus SPDYE5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE5→partner) and Y-score (partner→SPDYE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CRYGA →	+0.154	+5.497	<.001	.004	3	2
CESC	MTATP6P21 →	+0.218	+5.418	<.001	.005	3	2
CESC	RNA5SP367 →	+0.537	+5.010	<.001	.009	3	2
UCEC	RNU6-1213P →	+0.325	+4.292	<.001	<.001	3	2
UCEC	PACSIN2 →	+0.715	+3.191	<.001	.009	3	1
UCEC	CAB39L →	+0.615	+3.502	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

CRYGA by SPDYE5 expression — BLCA

Explore this box plot interactively →