SPDYE5

Across TCGA patient cohorts, SPDYE5 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE5-associated genes across cancer lineages are Tuberin, VHL, and Fibronectin. Each is linked with SPDYE5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE5-to-partner and partner-to-SPDYE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by SPDYE5-low versus SPDYE5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE5→partner) and Y-score (partner→SPDYE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.421	+3.169	.004	.020	2	1
UCEC	VHL →	-1.334	-3.169	<.001	.019	2	1
UCEC	Fibronectin →	-0.494	-3.169	.006	.020	1	1
UCEC	Di-Ras3 →	-0.285	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Tuberin by SPDYE5 expression — UCEC

Explore this box plot interactively →