SPDYE5

Across TCGA cell cohorts, SPDYE5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,438 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPDYE5-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with SPDYE5 in more than 18 cancer types. Because this analysis shows association rather than direction, both SPDYE5-to-partner and partner-to-SPDYE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by SPDYE5-low versus SPDYE5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE5→partner) and Y-score (partner→SPDYE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.201	+0.334	<.001	<.001	3	19
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.150	+0.272	<.001	<.001	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.176	+0.328	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.092	+0.274	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.160	+0.396	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.154	+0.383	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,438 associations by consensus.

Pre-mRNA catabolic process by SPDYE5 expression — BONE

Explore this box plot interactively →