Across TCGA pan-cancer cohorts, SPDYE4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPDYE4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPDYE4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SPDYE4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, DLBC, and READ are the cancer types where SPDYE4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.534	.023	24	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
READ	DFS	Median	II,III,IV	0.082	0.800	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPDYE4 tumor-vs-normal RNA expression · all SPDYE4 data types