Across TCGA patient cohorts, SPDYE3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,767 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPDYE3-associated proteins across cancer lineages are DDX42, PNN, and SF3B3. Each is linked with SPDYE3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPDYE3-to-partner and partner-to-SPDYE3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE3→partner) and Y-score (partner→SPDYE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX42 →	+0.232	+0.377	<.001	<.001	3	5
GBM	PNN →	+0.324	+0.410	.003	.001	3	5
LSCC	SF3B3 →	+0.240	+0.368	<.001	<.001	3	5
HNSC	GPATCH11 →	+0.362	+0.644	<.001	<.001	3	5
HNSC	SRSF9 →	+0.371	+0.497	<.001	.002	3	4
HNSC	ZNF219_S114 →	+0.821	+0.551	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,767 associations by consensus.

Exploration

SPDYE3 survival (RNA) · tumor vs normal (RNA) · all SPDYE3 data types