Across TCGA patient cohorts, SPDYE3 mutation is significantly associated with the RNA expression of many other genes, with 1,030 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE3-associated genes across cancer lineages are RNU6-1067P, RBPJP2, and PRR20E. Each is linked with SPDYE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE3-to-partner and partner-to-SPDYE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE3→partner) and Y-score (partner→SPDYE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1067P →	+0.512	+5.792	<.001	.003	3	2
LUSC	RBPJP2 →	+0.026	+5.273	.005	.006	3	2
STAD	PRR20E →	+0.009	+5.239	<.001	.002	3	2
UCEC	RN7SL283P →	+0.082	+2.868	<.001	.009	3	2
BRCA	MIR6507 →	+0.359	+8.055	<.001	.007	3	1
BRCA	RPPH1-2P →	+0.103	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,030 associations by consensus.

Exploration

SPDYE3 survival (RNA) · tumor vs normal (RNA) · all SPDYE3 data types