Across TCGA patient cohorts, SPDYE3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE3-associated genes across cancer lineages are Smad4, 14-3-3_beta, and p27_pT198. Each is linked with SPDYE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE3-to-partner and partner-to-SPDYE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE3→partner) and Y-score (partner→SPDYE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad4 →	-0.109	-2.302	.046	.034	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.021	.009	3	1
UCEC	p27_pT198 →	+0.108	+2.700	.025	.006	3	1
UCEC	p62 Lck ligand →	+0.317	+2.817	.030	.036	3	1
UCEC	P-Cadherin →	-0.152	-2.687	.019	.006	3	1
UCEC	Annexin-1 →	+0.633	+3.019	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

SPDYE3 survival (RNA) · tumor vs normal (RNA) · all SPDYE3 data types