Across TCGA cell cohorts, SPDYE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,752 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPDYE3-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of isotype switching to IgG isotypes, and Regulation of double-strand break repair. Each is linked with SPDYE3 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPDYE3-to-partner and partner-to-SPDYE3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE3→partner) and Y-score (partner→SPDYE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of isotype switching to IgG isotypes →	+0.127	+0.825	<.001	<.001	3	17
BLOOD_Lymphoma	Regulation of isotype switching to IgG isotypes →	+0.120	+0.880	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.085	+1.132	<.001	<.001	3	11
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.060	+0.517	<.001	<.001	3	11
LIVER	Mismatch repair →	+0.104	+0.714	.002	.008	3	11
LUNG_NSCLC_LUSC	Meiotic mismatch repair →	+0.130	+0.752	.003	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,752 associations by consensus.

Exploration

SPDYE3 survival (RNA) · tumor vs normal (RNA) · all SPDYE3 data types