Across TCGA cell cohorts, SPDYE3 mutation is significantly associated with the mutation status of many other genes, with 131 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPDYE3-associated genes across cancer lineages are AKAP10, CCT6B, and RPTN. Each is linked with SPDYE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE3-to-partner and partner-to-SPDYE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE3→partner) and Y-score (partner→SPDYE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AKAP10 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	CCT6B →	+4.429	+5.247	.005	.005	1	2
BLOOD_Lymphoma	RPTN →	+5.014	+5.584	.003	.003	1	1
BLOOD_Lymphoma	CYB5RL →	+5.014	+5.584	.003	.003	1	1
BLOOD_Lymphoma	CNTF →	+6.014	+6.014	.001	.001	1	1
BLOOD_Lymphoma	ZNF432 →	+5.014	+5.584	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

Exploration

SPDYE3 survival (RNA) · tumor vs normal (RNA) · all SPDYE3 data types