SPDYE20P

Across TCGA pan-cancer cohorts, SPDYE20P RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SPDYE20P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPDYE20P RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPDYE20P expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, KIRC, and THCA are the cancer types where SPDYE20P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.820	0.660	.002	81	view →
KIRC	OS	Median	II,III,IV	0.437	0.606	.003	24	view →
THCA	OS	Quartile	II,III,IV	0.867	0.966	.003	24	view →
SARC	OS	Tertile	All	0.300	0.648	.001	12	view →
LIHC	DFS	Quartile	II,III,IV	0.278	0.511	.016	10	view →
UVM	OS	Tertile	III,IV	0.227	0.692	.034	9	view →
ACC	OS	Quartile	III,IV	0.324	0.744	.008	9	view →
READ	DFS	Median	IV	0.179	0.936	.010	9	view →
TGCT	DFS	Median	All	0.725	0.866	.029	8	view →
UCEC	DFS	Median	All	0.867	0.913	.008	8	view →
KICH	DFS	Tertile	II,III,IV	0.565	0.908	.033	6	view →
CHOL	OS	Tertile	IV	0.234	1.000	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SPDYE20P–HNSC (OS)

Open the HNSC breakdown →