SPDYE19P

Across TCGA pan-cancer cohorts, SPDYE19P RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SPDYE19P data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SPDYE19P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPDYE19P expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

SKCM, OV, and COAD are the cancer types where SPDYE19P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	IV	0.729	0.155	<.001	62	view →
OV	DFS	Median	IV	0.337	0.567	.001	34	view →
COAD	DFS	Tertile	All	0.588	0.777	.004	28	view →
LUSC	DFS	Quartile	III,IV	0.320	0.933	.001	26	view →
UVM	DFS	Median	III,IV	0.337	0.677	.013	21	view →
READ	OS	Tertile	II,III,IV	1.000	0.872	.011	20	view →
LIHC	OS	Median	All	0.848	0.697	.014	19	view →
UCS	OS	Tertile	IV	0.844	0.222	.031	18	view →
KIRP	DFS	Median	IV	0.039	0.526	.016	18	view →
PRAD	DFS	Quartile	All	0.681	0.825	.012	18	view →
BRCA	DFS	Median	All	0.492	0.555	.009	11	view →
MESO	DFS	Median	All	0.280	0.571	.026	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SPDYE19P–SKCM (DFS)

Open the SKCM breakdown →